Structural optimization and prospect of constructing hemoglobin oxygen-oxygen carriers based on hemoglobin

The current global shortage of organ resources, the imbalance in donor-recipient demand and increasing number high-risk donors make preservation a necessity to consider appropriate storage options. method use often has risks such as blood group mismatch, short shelf life, susceptibility. HBOCs have positive effects anti-apoptotic, anti-inflammatory, antioxidant anti-proliferative, which significant advantages storage. Therefore, it is common pursuit researchers design synthesize with safety, ideal oxygen-carrying capacity, easy storage, etc. that are widely applicable optimal for different organs. There been recent advancement understanding mechanisms, discussed this review.